Letter from Nano Nagle to Miss [Eleanor] Fitzsimons discussing the establishment and success of her first schools in Cork, and the method of education employed therein. Nagle states that it is always a pleasure to hear from Fitzsimons. She also refers to early reactions to her ministry from the Nagle family, the circumstances of postulants travelling to the Ursuline monastery in Paris, the background of two new aspirants, Miss Coppinger and Miss Shea, and the recent outbreak of measles in Cork. Nagle declares, "If I could be of any service in saving souls in any part of the globe, I would willingly do all in my power".

Letter from Nano Nagle to Miss [Eleanor] Fitzsimons noting the writer's anxiety at not receiving letters from Fitzsimons or Dr. Moylan. Nagle comments that the proposed date of the novices’ arrival in Cork has not yet been fixed and discusses the problem of finding a professed religious to act as superior. A letter has been sent to Paris seeking a “categorical answer” as to whether the intended journey to Cork will go ahead. The author offers Miss Fitzsimons financial advice and recalls her own monetary woes, she notes that “money is at present so scarce, and such a run on the Bankers in this kingdome, that people cant get what is due to them”. Nagle shows her endearing concern for Mary Kavanagh, who is now teaching the poor children of Paris, and communicates her disappointment that the Ursulines will not come to Cork that winter.

Letter from Nano Nagle to Miss [Eleanor] Fitzsimons expressing her pleasure at receiving another letter from her and hoping they will meet in person soon. Nagle mentions her delight that Fitzsimons will be professed in Cork, and that the former novice mistress of the Ursuline monastery in Paris has consented to lead the new foundation in Ireland. She notes that [Francis] Moylan will do everything in his power to assist with this foundation. Nano is troubled to hear of her cousin's (Margaret Nagle) "histirick" or propensity to develop violent fits. The issue is causing some disagreement within the Ursuline community, who are under the impression that the disorder is contagious.

Letter from Nano Nagle to Miss [Eleanor] Fitzsimons in which she speculates about her investments in Paris and expresses her disappointment at the low interest paid. Nagle complains that Mr. Waters, banker, would not tell her anything about the East India Company. She appears fretful and vexed; fretful that the second effort at making an Ursuline foundation in Cork would fail again, and vexed that the interest paid by the East India Company had fallen to one half of its former value. Nagle asserts that it was the general opinion that few foreigners would ever again put their money in the French funds. She requests Miss Fitzsimons to present her compliments to her former mistress, communicates her affection for her correspondent, and mentions the young ladies and Miss Smith.

Letter from Nano Nagle to Teresa Mulally indicating that, at the behest of Dr. Moylan, she had taken in three women to assist in her education ministry the previous Christmas. She reveals that two of the women will establish a foundation in County Kerry and encloses a copy of their rule, "its called the sisters of the charitable instruction of the sacred heart of Jesus...I could wish that we may unite in this society, and am confident the great God will direct you to what is most for his glory".

Letter from Nano Nagle to Teresa Mulally in which she describes taking possession of her convent on 15 July 1780. The women were prevented from moving in immediately because the rear wall of the property had to be broken in order for carts to come in and deliver stones to build a "garden wall for the ladies". Nagle refers to the anti-Catholic Gordon Riots in London and her fear that "the same contagious frenzy may break out in this kingdome". She also discusses her dismissal of Miss Wolf, conveys greetings from Dr. Moylan, sends news of mutual acquaintances, and reports an improvement in her eye condition.

Letter sent from Bath, England, written while Nano is visiting her brothers there. She alludes to previous correspondence which detailed the foundation of her first schools in Cork, and how she withheld this from her family who until lately were uninformed of her work. While aware that her actions run contrary to Penal Laws, she is determined to continue. Nagle also writes that she has recently objected to a suggestion put forth by Mr. [Bryan Keating], merchant, South Mall, Cork, and Dr. [John] Butler, Bishop of Cork, to seek Protestant approval for the new Ursuline foundation in Cork; she leaves it to Miss [Eleanor] Fitzsimons to judge.

Letter from Nano Nagle to Miss [Eleanor] Fitzsimons giving an account of a "very desirable" young lady (Miss Lawless) whom she is seeking to take on in Cork. The lady's father is strongly opposed to her taking the veil and he has offered her a substantial sum of money should she reconsider and marry. The father's uncertainty also reflects the wider political climate of the period, Nagle notes "...he says there is a probability in France they may Demolish all the Monasteries". Nagle affirms Miss Fitzsimons and advises her to choose "any young lady you think proper" to enter the novitiate in Paris. Nagle's agitation over bringing the Ursulines to Cork is also apparent, "I hope your fortitude will bring you true all crosses and put a happy conclusion to this foundation".